Metabolic profiling of fatty acids in Tripterygium wilfordii multiglucoside- and triptolide-induced liver-injured rats
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چکیده
منابع مشابه
Urine metabolic changes in rats after tripterygium wilfordii poisoning
Tripterygium wilfordii (Hook. f.) is a woody vine of the Celastraceae family, and native to China (south of the Yangtze River), Korea, and Japan, is used in the clinic for the treatment of inflammatory and autoimmune diseases, especially rheumatoid arthritis. In this study, we developed a urine metabolomic method by gas chromatographymass spectrometry (GC-MS) to evaluate the effect of Tripteryg...
متن کاملDifferent modulation of Panax notoginseng on the absorption profiling of triptolide and tripterine from Tripterygium wilfordii in rat intestine
Background Compatibility with Panax notoginseng (PN) reduced the plasma concentration of triptolide and delayed the Tmax of Tripterygium wilfordii (TW), the sovereign medicine of Qing-Luo Tong-Bi decoction, which hinted the absorption process of triptolide might be involved in decreasing the toxicity in liver and kidney. Methods The absorption of triptolide, triptonide, wilforlide and tripter...
متن کاملDetermination of Triptonide and Triptolide in Multi-glycosides Tripterygium Wilfordii Tablets by Capillary Electrophoresis
A capillary electrophoresis method has been established for the determination of triptonide and triptolide in Multi-glycosides Tripterygium wilfordii tablets. Capillary separation was carried out by using 0.01mol L borax + 0.02 mol L boric acid + 0.02 mol L SDS (pH = 8.0) as the buffer, a fused – silica capillary tube column (60.2 cm × 75μm id. 52.6 cm of effective length) as the separation cha...
متن کاملIsolation and Purification of Triptolide from the Leaves of Tripterygium wilfordii Hook F
Triptolide is an important active component of Tripterygium wilfordii Hook F (TWHF) and possesses anti-inflammatory, immunosuppressive, male anti-fertility, and anticancer properties. A new method combining different techniques, including solid-liquid extraction, liquid-liquid partition, column chromatography and high-speed counter-current chromatography (HSCCC) but avoiding the use of chlorofo...
متن کاملA Mechanistic Overview of Triptolide and Celastrol, Natural Products from Tripterygium wilfordii Hook F
Triptolide and celastrol are predominantly active natural products isolated from the medicinal plant Tripterygium wilfordii Hook F. These compounds exhibit similar pharmacological activities, including anti-cancer, anti-inflammation, anti-obesity, and anti-diabetic activities. Triptolide and celastrol also provide neuroprotection and prevent cardiovascular and metabolic diseases. However, toxic...
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ژورنال
عنوان ژورنال: Open Life Sciences
سال: 2021
ISSN: 2391-5412
DOI: 10.1515/biol-2021-0016